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EGFR-HER2 inhibitor AZD3759, Purity ≥98%

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Cat. No.: X24-05-ZQ657

EGFR-HER2 inhibitor AZD3759, Purity ≥98%

Synonym: 1626387-80-1; AZD 3759; EGFR-HER2 inhibitor

CAS Number: 1626387-80-1
Compound CID: 78209992

Product Size

10 mg; 25 mg; 50 mg

Price

Datasheet

MSDS

Properties

Description

AZD3759, soluble in DMSO and warmed ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR (exon 19Del), EGFR (L858R), and EGFR (WT).

Molecular Weight

459.9

Molecular Formula

C₂₂H₂₃ClFN₅O₃

Targets

EGFR (exon 19Del): 0.2 nM; EGFR (L858R): 0.2 nM; EGFR (WT): 0.3 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 80 mg/mL (173.94 mM); Water: Insoluble; Warmed ethanol: 18 mg/mL (39.13 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZD3759 is investigated for its selective inhibition of EGFR and its implications in treating brain metastases from non-small cell lung cancer.

Publications

Publications (0)

Publications

Publications

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