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EGFR-HER2 inhibitor WZ4002, Purity ≥98%
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Cat. No.: X23-10-ZQ1045

EGFR-HER2 inhibitor WZ4002, Purity ≥98%

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Synonym: WZ4002; 1213269-23-8; WZ-4002; N-(3-(5-Chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide; EGFR-HER2 inhibitor

  • CAS Number: 1213269-23-8
  • Compound CID: 44607530
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Product Size
10 mg; 25 mg; 50 mg; 100 mg; 200 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
WZ4002, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR (L858R) (BaF3 cells) and EGFR (L858R/T790M) (BaF3 cells).
Molecular Weight
495
Molecular Formula
C25H27ClN6O3
Targets
EGFR (L858R) (BaF3 cells): 2 nM; EGFR (L858R/T790M) (BaF3 cells): 8 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 12 mg/mL (24.28 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
WZ4002 can be used to inhibit mutant EGFR (T790M) and help in studying resistance mechanisms in cancer therapy.
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