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ERK inhibitor TCS ERK 11e, Purity ≥98%
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Cat. No.: X23-10-ZQ863

ERK inhibitor TCS ERK 11e, Purity ≥98%

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Synonym: VX-11E; 896720-20-0; Vertex-11E; VTX-11E; TCS ERK 11E; 4-[2-(2-Chloro-4-fluoroanilino)-5-methylpyrimidin-4-yl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide; ERK inhibitor

  • CAS Number: 896720-20-0
  • Compound CID: 11634725
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Product Size
10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
TCS ERK 11e, soluble in DMSO and ethanol and insoluble in water, exhibits potent inhibition of ERK kinase. It targets ERK2, GSK3, AURA, and CDK2.
Molecular Weight
500.35
Molecular Formula
C24H20Cl2FN5O2
Targets
ERK2: <2 nM (Ki); GSK3: 400 nM (Ki); AURA: 540 nM (Ki); CDK2: 850 nM (Ki)
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 94 mg/mL (187.87 mM); Water: Insoluble; Ethanol: 15 mg/mL (29.97 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
TCS ERK 11e can be used to study the selective inhibition of ERK1/2 in signal transduction pathways.
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