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FLT3 inhibitor G-749, Purity ≥98%

Cat. No.: X24-06-ZQ185

FLT3 inhibitor G-749, Purity ≥98%

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Synonym: 1457983-28-6; FLT3 inhibitor; G749

  • MDL: MFCD28167815
  • CAS Number: 1457983-28-6
  • Compound CID: 78357765
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Product Size
5 mg; 10 mg; 25 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
G-749, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FLT3. It targets FLT3 (D835Y), Mer, Aurora B, AuroraC, Axl, c-Kit, FGFR1, FGFR3, FLT3, Fms, and IGF-1R.
Molecular Weight
521.41
Molecular Formula
C25H25BrN6O2
Targets
FLT3 (D835Y): 0.6 nM; Mer: 1 nM; AuroraB: 6 nM; AuroraC: 24 nM; Axl: 20 nM; c-Kit: 142 nM; FGFR1: 25 nM; FGFR3: 30 nM; FLT3: 0.4 nM; Fms: 19 nM; IGF-1R: >300 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
Warmed DMSO: 22 mg/mL (42.19 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
G-749 is used as a FLT3 inhibitor in cancer studies exploring its effects on disrupting leukemia cell signaling.
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