Cat. No.: X24-06-ZQ192
FLT3 inhibitor MLN518, Purity ≥98%
Synonym: 387867-13-2; FLT3 inhibitor; MLN-518; CT53518
- MDL: MFCD09954147
- CAS Number: 387867-13-2
- Compound CID: 3038522
Product Size
25 mg; 50 mg; 100 mg; 200 mg
Properties
Description
MLN518, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FLT3. It targets Flt3, PDGFRβ, Abl, c-Kit, CSF-1R, EGFR, ERK2, FGFR, Insulin receptor, KDR, and MEK1.
Molecular Formula
C31H42N6O4
Targets
Flt3: 0.22 μM; PDGFRβ: 0.2 μM; Abl: >30 μM; c-Kit: 0.17 μM; CSF-1R: 3.43 μM; EGFR: >30 μM; ERK2: >30 μM; FGFR: >30 μM; Insulin receptor: >30 μM; KDR: >30 μM; MEK1: >30 μM
Solubility
DMSO: 5 mg/mL (8.88 mM); Water: Insoluble; Ethanol: 6 mg/mL (10.66 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
MLN518 functions as a FLT3 inhibitor in research focused on interactions in leukemia pathogenesis and therapy.
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