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IGF-1R inhibitor BMS-536924, Purity ≥98%
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Cat. No.: X24-06-ZQ282

IGF-1R inhibitor BMS-536924, Purity ≥98%

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Synonym: 468740-43-4; IGF-1R inhibitor; BMS536924

  • CAS Number: 468740-43-4
  • Compound CID: 135440466
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Product Size
5 mg; 10 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
BMS-536924, soluble in DMSO and insoluble in ethanol and water, blocks the insulin-like growth factor 1 receptor (IGF-1R) signaling pathway, which plays a crucial role in cell growth and survival. It targets FAK, IGF-1R, Akt1, CDK2/CyclinE, EGF, HER2, Insulin receptor, LCK, MAPK1, MAPK2, and MEK.
Molecular Weight
480
Molecular Formula
C25H26ClN5O3
Targets
FAK: 150 nM; IGF-1R: 100 nM; Akt1: >5 μM; CDK2/CyclinE: >1 μM; EGF: 1.6 μM; HER2: 17.1 μM; Insulin receptor: 73 nM; LCK: 341 nM; MAPK1: >5 μM; MAPK2: 5 μM; MEK: 182 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 92 mg/mL (191.68 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
BMS-536924 is utilized to explore IGF-1 receptor inhibition and its therapeutic potential in cancer and metabolic disorder research.
Publications
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