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IGF-1R inhibitor GSK1838705A, Purity ≥98%
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Cat. No.: X24-06-ZQ283

IGF-1R inhibitor GSK1838705A, Purity ≥98%

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Synonym: 1116235-97-2; IGF-1R inhibitor; GSK-1838705A

  • MDL: MFCD19443644
  • CAS Number: 1116235-97-2
  • Compound CID: 25182616
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Product Size
5 mg; 10 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
GSK1838705A, soluble in DMSO and insoluble in ethanol and water, blocks the insulin-like growth factor 1 receptor (IGF-1R) signaling pathway, which plays a crucial role in cell growth and survival. It targets IGF-1R, Insulin receptor, Akt1, Akt2, ALK, ALK5, ASK1, Aurora A, AuroraB, B-Raf(V600E), and CaMKK2.
Molecular Weight
532.57
Molecular Formula
C27H29FN8O3
Targets
IGF-1R: 2 nM; Insulin receptor: 1.6 nM; Akt1: >10 μM; Akt2: >10 μM; ALK: 0.5 nM; ALK5: >10 μM; ASK1: >25 μM; AuroraA: >10 μM; AuroraB: >10 μM; B-Raf (V600E): >2 μM; CaMKK2: >10 μM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 103 mg/mL (193.4 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
GSK1838705A is employed in studies aiming to inhibit IGF-1 receptor signaling, relevant for cancer treatment development.
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