BI-847325, soluble in warmed DMSO and ethanol and insoluble in water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets Aurora A (human), Aurora B (Xenopus laevis), Aurora C (human), MEK1, and MEK2.
Molecular Weight
464.56
Molecular Formula
C29H28N4O2
Targets
Aurora A (Human): 25 nM; Aurora B (Xenopus laevis): 3 nM; Aurora C (Human): 15 nM; MEK1: 25 nM; MEK2: 4 nM
BI-847325 can be employed to study dual inhibition of MEK and Aurora kinases in cancer research.
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