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MEK inhibitor GSK1120212, Purity ≥98%
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Cat. No.: X23-10-ZQ824

MEK inhibitor GSK1120212, Purity ≥98%

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Synonym: Trametinib; 871700-17-3; GSK1120212; Mekinist; GSK-1120212; JTP 74057; JTP-74057; MEK inhibitor

  • MDL: MFCD17215075
  • CAS Number: 871700-17-3
  • Compound CID: 11707110
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
GSK1120212, soluble in DMSO and insoluble in ethanol and water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets MEK1 and MEK2.
Molecular Weight
615.4
Molecular Formula
C26H23FIN5O4
Targets
MEK1: 0.92 nM; MEK2: 1.8 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 19 mg/mL (30.87 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
GSK1120212 (Trametinib) can be used to investigate the inhibition of MEK1 and MEK2 in the MAPK/ERK signaling pathway, which is often implicated in cancer.
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