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MEK inhibitor U0126-EtOH, Purity ≥98%
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Cat. No.: X23-10-ZQ828

MEK inhibitor U0126-EtOH, Purity ≥98%

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Synonym: U0126-EtOH; 1173097-76-1; U0126 Ethanol; U0126.EtOH; (2Z,3Z)-2,3-Bis(amino(2-aminophenylthio)methylene)succinonitrile compound with ethanol (1:1); (2Z,3Z)-2,3-Bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile; MEK inhibitor

  • CAS Number: 1173097-76-1
  • Compound CID: 16220066
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Product Size
25 mg; 50 mg; 100 mg; 250 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
U0126-EtOH, soluble in DMSO and insoluble in ethanol and water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets Abl, CDK2, and CDK4.
Molecular Weight
426.6
Molecular Formula
C18H16N6S2.C2H6O
Targets
Abl: 100 μM; CDK2: 10 μM; CDK4: 10 μM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 77 mg/mL (180.51 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
U0126-EtOH can be used to study the inhibition of MEK1/2 and its downstream effects on ERK phosphorylation in signal transduction pathways.
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