Raf inhibitor Dabrafenib mesylate, Purity ≥98%

Name: Raf inhibitor Dabrafenib mesylate, Purity ≥98%
SKU: X23-10-ZQ974

Synonym: Dabrafenib mesylate; 1195768-06-9; Dabrafenib (Mesylate); Taflinar; GSK 2118436B; UNII-B6DC89I63E; GSK-2118436B; Raf inhibitor

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Dabrafenib mesylate, soluble in DMSO and ethanol and insoluble in water, blocks a MAPK/ERK signaling pathway. It targets BRAF V600E and CRAF.

Molecular Weight

615.67

Molecular Formula

C₂₄H₂₄F₃N₅O₅S₃

Targets

BRAF V600E: 0.6 nM; CRAF: 5 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 96 mg/mL (155.92 mM); Water: Insoluble; Ethanol: 5 mg/mL (8.12 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Dabrafenib mesylate can be used to investigate the inhibition of BRAF V600E and its therapeutic role in melanoma.