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Raf inhibitor PLX-4720, Purity ≥98%
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Cat. No.: X23-10-ZQ936

Raf inhibitor PLX-4720, Purity ≥98%

Synonym: 918505-84-7; PLX-4720; PLX4720; N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide; PLX 4720; N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide; N-[3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide; Raf inhibitor

  • MDL: MFCD14635203
  • CAS Number: 918505-84-7
  • Compound CID: 24180719
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Product Size
1 mg; 2 mg; 5 mg; 10 mg; 25 mg
Price
Datasheet
MSDS
Properties
Description
PLX-4720, soluble in DMSO and insoluble in ethanol and water, blocks a MAPK/ERK signaling pathway. It targets BRAF V600E, BRK, Aurora A, and B-Raf.
Molecular Weight
413.8
Molecular Formula
C17H14ClF2N3O3S
Targets
BRAF V600E: 13 nM; BRK: 130 nM; Aurora A: 3.4 μM; B-Raf: 160 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 81 mg/mL (195.73 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
PLX-4720 is employed in studies to investigate the selective inhibition of the BRAFV600E mutant kinase in melanoma and other cancers.
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