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Raf inhibitor PLX4032, Purity ≥98%
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Cat. No.: X23-10-ZQ954

Raf inhibitor PLX4032, Purity ≥98%

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Synonym: Vemurafenib; 918504-65-1; PLX4032; Zelboraf; 1029872-54-5; PLX-4032; N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide; Raf inhibitor

  • MDL: MFCD18074504
  • CAS Number: 918504-65-1
  • Compound CID: 42611257
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Product Size
10 mg; 25 mg; 50 mg; 100 mg; 200 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
PLX4032, soluble in DMSO and insoluble in ethanol and water, blocks a MAPK/ERK signaling pathway. It targets ACK1, B-Raf (V600E), B-Raf, and BLK.
Molecular Weight
489.9
Molecular Formula
C23H18ClF2N3O3S
Targets
ACK1: 19 nM; B-Raf (V600E): 31 nM; B-Raf: 100 nM; BLK: 547 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 83 mg/mL (169.41 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
PLX4032 can be utilized to study BRAF V600E and associated melanoma treatments by inhibiting mutant BRAF.
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