Cat. No.: X23-10-ZQ016
Bcl-2 antagonist A-1155463, Purity ≥98%
Synonym: 1235034-55-5; A-1155463; A1155463; 2-[8-(1,3-Benzothiazol-2-Ylcarbamoyl)-3,4-Dihydroisoquinolin-2(1H)-Yl]-5-(3-{4-[3-(dimethylamino)prop-1-Yn-1-Yl]-2-fluorophenoxy}propyl)-1,3-thiazole-4-carboxylic acid; Bcl-2 antagonist
- MDL: MFCD29924714
- CAS Number: 1235034-55-5
- Compound CID: 59447577
Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Properties
Description
A-1155463, soluble in DMSO and insoluble in ethanol and water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets BCL-XL, Bcl-w, Bcl-2, and Mcl-1.
Molecular Formula
C35H32FN5O4S2
Targets
BCL-XL: 440 nM (Ki); Bcl-w; Bcl-2; Mcl-1
Solubility
DMSO: 78 mg/mL (116.45 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
A-1155463 can be used to study its functional contribution to cell survival in physiological and pathophysiological conditions.
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