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Bcl-2 inhibitor A-1331852, Purity ≥98%

Cat. No.: X23-10-ZQ017

Bcl-2 inhibitor A-1331852, Purity ≥98%

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Synonym: 1430844-80-6; A1331852; A-1331852; 3-[1-(1-Adamantylmethyl)-5-methylpyrazol-4-yl]-6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]pyridine-2-carboxylic acid; Bcl-2 inhibitor

  • MDL: MFCD30532662
  • CAS Number: 1430844-80-6
  • Compound CID: 71565985
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
A-1331852, soluble in DMSO and insoluble in ethanol and water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets BCL-XL, Bcl-w, Bcl-2, and Mcl-1.
Molecular Weight
658.82
Molecular Formula
C38H38N6O3S
Targets
BCL-XL: <0.01 nM (Ki); Bcl-w: 4 nM (Ki); Bcl-2: 6 nM (Ki); Mcl-1: 142 nM (Ki)
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 91 mg/mL (138.12 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
A-1331852 can be used to explore its role in apoptosis and potential as a therapeutic target for cancer treatment.
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Blood Group and Lewis Antigen
Blood group A trisaccharide (Cat#: XCO0060Q) Blood group B trisaccharide (Cat#: XCO0068Q) Blood group H disaccharide (Cat#: XCO0074Q) Lewis A trisaccharide (Cat#: XCO0079Q) 3'-Sulfated lewis A (Cat#: XCO0080Q) Lewis B tetrasaccharide (Cat#: XCO0083Q) Lewis X trisaccharide (Cat#: XCO0085Q) Lewis Y tetrasaccharide (Cat#: XCO0088Q)
Human Milk Oligosaccharides (HMOs)
Lacto-N-biose (Cat#: XCO0089Q) 2'-Fucosyllactose (Cat#: XCO0091Q) 3-Fucosyllactose (Cat#: XCO0092Q) Lactodifucotetraose (Cat#: XCO0093Q) Lacto-N-triose I (Cat#: XCO0094Q) 3'-Sialyllactose sodium salt (Cat#: XCO0096Q) 6'-Sialyllactose sodium salt (Cat#: XCO0098Q) 3'-Sialyl-3-fucosyllactose (Cat#: XCO0100Q)
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