Cat. No.: X23-10-ZQ035
Bcl-2 inhibitor AT101 acetic acid, Purity ≥98%
Synonym: 12542-36-8; 866541-93-7; Gossypol acetic acid; Gossypol-acetic acid; Gossypol acetate; Acetate gossypol; AT101; 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde acetate salt; Bcl-2 inhibitor
- MDL: MFCD00058385
- CAS Number: 866541-93-7
- Compound CID: 227456
Product Size
10 mg; 25 mg; 50 mg; 100 mg
Properties
Description
AT101 acetic acid, soluble in DMSO and ethanol and insoluble in water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets Mcl-1, Bcl-2, and Bcl-xL.
Molecular Formula
C30H30O8.C2H4O2
Targets
Mcl-1: 0.18 μM (Ki); Bcl-2: 0.32 μM (Ki); Bcl-xL: 0.48 μM (Ki)
Solubility
DMSO: 108 mg/mL (186.65 mM); Water: Insoluble; Ethanol: 83 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
AT101 acetic acid can be applied to research involving the inhibition of Bcl-2 family proteins and its effects on inducing apoptosis in cancer cells.
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