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Bcl-2 inhibitor Sabutoclax, Purity ≥98%
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Cat. No.: X23-10-ZQ009

Bcl-2 inhibitor Sabutoclax, Purity ≥98%

Synonym: 1228108-65-3; Sabutoclax; BI-97C1; 39Y89ZRK34; (1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-[2,2'-binaphthalene]-5,5'-dicarboxamide; 2,3,5-Trihydroxy-7-methyl-N-[(2R)-2-phenylpropyl]-6-[1,6,7-trihydroxy-3-methyl-5-[[(2R)-2-phenylpropyl]carbamoyl]naphthalen-2-yl]naphthalene-1-carboxamide; Bcl-2 inhibitor

  • CAS Number: 1228108-65-3
  • Compound CID: 46236925
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
MSDS
Properties
Description
Sabutoclax, soluble in warmed DMSO and warmed ethanol and insoluble in water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets Mcl-1, Bcl-xL, Bcl-2, and Bcl-1.
Molecular Weight
700.78
Molecular Formula
C42H40N2O8
Targets
Mcl-1: 0.20 μM; Bcl-xL: 0.31 μM; Bcl-2: 0.32 μM; Bcl-1: 0.62 μM
Form
Lyophilized powder
Purity
≥98%
Solubility
Warmed DMSO: 93 mg/mL (132.7 mM); Water: Insoluble; Warmed ethanol: 50 mg/mL (71.34 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
Sabutoclax can be used to study its role of Bcl-2 family proteins in anti-apoptotic signaling in various cellular models.
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