Cat. No.: X24-06-ZQ289
IGF-1R inhibitor OSI-906, Purity ≥98%
Synonym: 867160-71-2; IGF-1R inhibitor; OSI906; Linsitinib
- MDL: MFCD12912153
- CAS Number: 867160-71-2
- Compound CID: 11640390
Product Size
5 mg; 10 mg; 50 mg; 100 mg
Properties
Description
OSI-906, soluble in DMSO and insoluble in ethanol and water, blocks the insulin-like growth factor 1 receptor (IGF-1R) signaling pathway, which plays a crucial role in cell growth and survival. It targets Insulin receptor, IRR, Abl, Akt1, Akt2, ALK, Aurora A, AuroraB, BRK, BTK, and CDK1.
Molecular Formula
C26H23N5O
Targets
Insulin receptor: 75 nM; IRR: 75 nM; Abl: >10 μM; Akt1: >10 μM; Akt2: >10 μM; ALK: >10 μM; AuroraA: >10 μM; AuroraB: >10 μM; BRK: >10 μM; BTK: >10 μM; CDK1: >10 μM
Solubility
DMSO: 80 mg/mL (189.8 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
OSI-906 is applied to study IGF-1 receptor blocking, which plays a vital role in cancer and metabolic disease research.
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