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JAK inhibitor Gandotinib, Purity ≥98%
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Cat. No.: X23-10-ZQ395

JAK inhibitor Gandotinib, Purity ≥98%

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Synonym: GANDOTINIB; 1229236-86-5; LY2784544; LY 2784544; LY-2784544; Gandotinib (LY2784544); 3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine; JAK inhibitor

  • MDL: MFCD20482143
  • CAS Number: 1229236-86-5
  • Compound CID: 46213929
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Gandotinib, soluble in DMSO and ethanol and insoluble in water, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK2, JAK2, ALK, Aurora A, FGFR2, FGFR3, FLT3, FLT4, JAK1, JAK2 (V617F), and JAK3.
Molecular Weight
469.9
Molecular Formula
C23H25ClFN7O
Targets
JAK2: 0.288 nM (Ki); JAK2: 2.52 nM; ALK: 138 nM; Aurora A: 168 nM; FGFR2: 32 nM; FGFR3: 106 nM; FLT3: 4 nM; FLT4: 25 nM; JAK1: 19.8 nM; JAK2 (V617F): 0.245 nM (Ki); JAK3: 48.0 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 92 mg/mL (195.76 mM); Water: Insoluble; Ethanol: 9 mg/mL (19.15 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
Gandotinib can be utilized to study the inhibition of JAK2 activity in various biological assays.
Publications
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