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JAK inhibitor TCS 21311, Purity ≥98%
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Cat. No.: X23-10-ZQ420

JAK inhibitor TCS 21311, Purity ≥98%

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Synonym: TCS 21311; 1260181-14-3; NIBR3049; 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; TCS-21311; CLGRAWDGLMENOD-UHFFFAOYSA-N; JAK inhibitor

  • CAS Number: 1260181-14-3
  • Compound CID: 50925411
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Product Size
10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
TCS 21311 is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets GSK-3β, JAK1, JAK2, JAK3, PKCα, and PKCθ.
Molecular Weight
526.51
Molecular Formula
C27H25F3N4O4
Targets
GSK-3β: 3 nM; JAK1: 1.017 μM; JAK2: 2.55 μM; JAK3: 8 nM; PKCα: 13 nM; PKCθ: 68 nM
Form
Lyophilized powder
Purity
≥98%
Identity
Confirmed by NMR/HPLC/MS.
Applications
TCS 21311 can be used to explore the inhibition of Tyk2 and JAK1/2 kinase activity in autoimmune and inflammatory conditions.
Publications
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