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JAK inhibitor Tofacitinib, Purity ≥98%
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Cat. No.: X23-10-ZQ424

JAK inhibitor Tofacitinib, Purity ≥98%

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Synonym: Tofacitinib; 477600-75-2; Tasocitinib; 3-((3R,4R)-4-Methyl-3-(methyl(7S-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; JAK inhibitor

  • MDL: MFCD11035919
  • CAS Number: 477600-75-2
  • Compound CID: 9926791
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Product Size
50 mg; 100 mg; 250 mg; 500 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Tofacitinib, soluble in warmed DMSO and insoluble in water and ethanol, is an available JAK small molecule inhibitor with potential antineoplastic activity. It targets JAK1, JAK2, JAK3, Lck, and Rock-II.
Molecular Weight
312.37
Molecular Formula
C16H20N6O
Targets
JAK1: 112 nM; JAK2: 20 nM; JAK3: 1 nM; Lck: 3870 nM; Rock-II: 3400 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
Warmed DMSO: 56 mg/mL (179.27 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Tofacitinib can be used to investigate its JAK1/3 inhibition for research in rheumatoid arthritis and other inflammatory diseases.
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