Cat. No.: X23-12-YM012
LY364947
Synonym: 396129-53-6; HTS 466284; TGF-β RI Kinase Inhibitor; 4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)quinoline
- CAS Number: 396129-53-6
- PubChem CID: 447966
Product Size
10 mg; 25 mg; 50 mg; 100 mg
Properties
Description
LY364947, soluble in DMSO and insoluble in water and ethanol, blocks the function of Smad proteins in the TGF-β signaling pathway. It targets CK1δ (cell-free assay), MLK-7K (cell-free assay), RIPK2 (cell-free assay), TGFβRI (cell-free assay), and TGFβRII (cell-free assay).
Molecular Formula
C17H12N4
Targets
CK1δ (Cell-free assay): 0.22 μM; MLK-7K (Cell-free assay): 1.4 μM; RIPK2 (Cell-free assay): 0.11 μM; TGFβRI (Cell-free assay): 59 nM; TGFβRII (Cell-free assay): 0.4 μM
Solubility
DMSO: 1 mg/mL (3.67 mM); Water: insoluble; Ethanol: insoluble
Applications
LY364947 can be used as a pharmacological tool to investigate the role of mGluR1 in various neurobiological processes.
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