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MEK inhibitor BIX 02189, Purity ≥98%
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Cat. No.: X23-10-ZQ830

MEK inhibitor BIX 02189, Purity ≥98%

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Synonym: BIX02189; BIX 02189; 1094614-85-3; 1265916-41-3; BIX-02189; (Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide; MEK inhibitor

  • CAS Number: 1094614-85-3
  • Compound CID: 135659062
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
BIX 02189, soluble in DMSO and ethanol and insoluble in water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets EGFR, ERK1, and ERK5.
Molecular Weight
440.5
Molecular Formula
C27H28N4O2
Targets
EGFR: >6.3 μM; ERK1: >6.2 μM; ERK5: 59 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 56 mg/mL (127.11 mM); Water: Insoluble; Ethanol: 75 mg/mL (170.24 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
BIX 02189 can be used to examine the specific inhibition of MEK5 in the ERK5 signaling pathway.
Publications
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