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MEK inhibitor BIX02188, Purity ≥98%
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Cat. No.: X23-10-ZQ855

MEK inhibitor BIX02188, Purity ≥98%

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Synonym: BIX02188; 1094614-84-2; 334949-59-6; BIX-02188; BIX 02188; (Z)-3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide; (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide; MEK inhibitor

  • CAS Number: 1094614-84-2, 334949-59-6
  • Compound CID: 135398492
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
BIX02188, soluble in DMSO and ethanol and insoluble in water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets EGFR, ERK1, ERK5, and JNK2.
Molecular Weight
412.5
Molecular Formula
C25H24N4O2
Targets
EGFR: >6.3 μM; ERK1: >6.3 μM; ERK5: 810 nM; JNK2: >6.3 μM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 39 mg/mL (94.54 mM); Water: Insoluble; Ethanol: 3 mg/mL (7.27 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
BIX02188 can be used to study the selective inhibition of MEK5 in various cellular contexts.
Publications
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