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Cat. No.: X23-10-ZQ858

MEK inhibitor RO5126766, Purity ≥98%

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Synonym: 946128-88-7; RO5126766; Avutometinib; CH5126766; RO-5126766; RO-5126766 free base; Ro 5126766; MEK inhibitor

  • CAS Number: 946128-88-7
  • Compound CID: 16719221
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
RO5126766, soluble in DMSO and insoluble in ethanol and water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets BRAF V600E, B-Raf, CRAF, and MEK1.
Molecular Weight
471.5
Molecular Formula
C21H18FN5O5S
Targets
BRAF V600E; B-Raf: 19 nM; CRAF: 56 nM; MEK1: 160 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 93 mg/mL (197.26 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
RO5126766 can be used to study dual inhibition of RAF and MEK signaling pathways in cancer research.
Publications
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