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TGF-β-Smad inhibitor LDN193189, Purity ≥98%
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Cat. No.: X23-10-ZQ816

TGF-β-Smad inhibitor LDN193189, Purity ≥98%

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Synonym: 1062368-24-4; LDN193189; LDN-193189; 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline; LDN 193189; 4-[6-(4-Piperazin-1-Ylphenyl)pyrazolo[1,5-A]pyrimidin-3-Yl]quinoline; LDN193189 free base; TGF-β-Smad inhibitor

  • MDL: MFCD17169988
  • CAS Number: 1062368-24-4
  • Compound CID: 25195294
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Product Size
2 mg; 5 mg; 10 mg; 25 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
LDN193189, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of TGF-β-Smad signaling pathway activation. It targets ALK2 (C2C12 cells) and ALK3 (C2C12 cells).
Molecular Weight
406.48
Molecular Formula
C25H22N6
Targets
ALK2 (C2C12 cells): 5 nM; ALK3 (C2C12 cells): 30 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: Insoluble; Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
LDN193189 can be used to explore its inhibition of BMP type I receptors and its role in regulating cell differentiation and growth.
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