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TGF-β-Smad inhibitor LY2157299, Purity ≥98%
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Cat. No.: X23-10-ZQ811

TGF-β-Smad inhibitor LY2157299, Purity ≥98%

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Synonym: Galunisertib; 700874-72-2; LY2157299; LY 2157299; LY-2157299; 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide; TGF-β-Smad inhibitor

  • MDL: MFCD12923319
  • CAS Number: 700874-72-2
  • Compound CID: 10090485
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
LY2157299, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of TGF-β-Smad signaling pathway activation. It targets TβRI.
Molecular Weight
369.4
Molecular Formula
C22H19N5O
Targets
TβRI: 56 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 66 mg/mL (178.65 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
LY2157299 can be used to study its inhibition of TGF-β receptor I kinase and its potential therapeutic applications in fibrosis and cancer.
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Blood Group and Lewis Antigen
Blood group A trisaccharide (Cat#: XCO0060Q) Blood group B trisaccharide (Cat#: XCO0068Q) Blood group H disaccharide (Cat#: XCO0074Q) Lewis A trisaccharide (Cat#: XCO0079Q) 3'-Sulfated lewis A (Cat#: XCO0080Q) Lewis B tetrasaccharide (Cat#: XCO0083Q) Lewis X trisaccharide (Cat#: XCO0085Q) Lewis Y tetrasaccharide (Cat#: XCO0088Q)
Human Milk Oligosaccharides (HMOs)
Lacto-N-biose (Cat#: XCO0089Q) 2'-Fucosyllactose (Cat#: XCO0091Q) 3-Fucosyllactose (Cat#: XCO0092Q) Lactodifucotetraose (Cat#: XCO0093Q) Lacto-N-triose I (Cat#: XCO0094Q) 3'-Sialyllactose sodium salt (Cat#: XCO0096Q) 6'-Sialyllactose sodium salt (Cat#: XCO0098Q) 3'-Sialyl-3-fucosyllactose (Cat#: XCO0100Q)
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