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TGF-β-Smad inhibitor LY2157299, Purity ≥98%
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Cat. No.: X23-10-ZQ811

TGF-β-Smad inhibitor LY2157299, Purity ≥98%

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Synonym: Galunisertib; 700874-72-2; LY2157299; LY 2157299; LY-2157299; 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide; TGF-β-Smad inhibitor

  • MDL: MFCD12923319
  • CAS Number: 700874-72-2
  • Compound CID: 10090485
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
LY2157299, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of TGF-β-Smad signaling pathway activation. It targets TβRI.
Molecular Weight
369.4
Molecular Formula
C22H19N5O
Targets
TβRI: 56 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 66 mg/mL (178.65 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
LY2157299 can be used to study its inhibition of TGF-β receptor I kinase and its potential therapeutic applications in fibrosis and cancer.
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