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TGF-β-Smad inhibitor SB 431542, Purity ≥98%
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Cat. No.: X23-10-ZQ805

TGF-β-Smad inhibitor SB 431542, Purity ≥98%

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Synonym: 301836-41-9; SB-431542; SB 431542; 4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide; SB431542; 4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE; TGF-β-Smad inhibitor

  • MDL: MFCD05865244
  • CAS Number: 301836-41-9
  • Compound CID: 4521392
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Product Size
10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
SB 431542, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of TGF-β-Smad signaling pathway activation. It targets ALK4, ALK5, and ALK7.
Molecular Weight
384.4
Molecular Formula
C22H16N4O3
Targets
ALK4; ALK5: 94 nM; ALK7
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 75 mg/mL (195.11 mM); Water: Insoluble; Ethanol: 3 mg/mL (7.8 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
SB 431542 can be used to study its inhibition of TGF-β1 receptor kinase and its effects on cellular processes such as proliferation and differentiation.
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