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TGF-β-Smad inhibitor SB-505124, Purity ≥98%
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Cat. No.: X23-10-ZQ815

TGF-β-Smad inhibitor SB-505124, Purity ≥98%

Synonym: 694433-59-5; SB-505124; SB505124; 2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine; SB 505124; TGF-beta RI Inhibitor III; 2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl)-6-methylpyridine; TGF-β-Smad inhibitor

  • MDL: MFCD20926329
  • CAS Number: 694433-59-5
  • Compound CID: 9858940
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
MSDS
Properties
Description
SB-505124, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of TGF-β-Smad signaling pathway activation. It targets ALK4 and ALK5.
Molecular Weight
335.4
Molecular Formula
C20H21N3O2
Targets
ALK4: 129 nM; ALK5: 47 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 65 mg/mL (193.8 mM); Water: Insoluble; Ethanol: 65 mg/mL (193.8 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
SB-505124 can be used to investigate its selective inhibition of TGF-β receptor I kinase and its effects on cellular responses to TGF-β signaling.
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