Role of Globo Antigen

Glycosylation is a complex form of post-translational modification that affects more than 50% of cellular proteins and is a key regulator of many eukaryotic processes. Aberrant glycosylation is a common feature of many cancers and plays a crucial role in all stages of tumor development. Different mechanisms of aberrant glycosylation lead to the formation of tumor-associated glycan antigens (TACA) suitable for selective tumor-targeted therapy. Among tumor-associated glycan antigens, Globo antigens are specifically expressed on pluripotent stem cells and many types of tumor cells, and cancer cells. Thus, globo antigens can serve as a source for the development of novel clinical biomarkers that provide a range of specific targets for therapeutic interventions and a prerequisite for the development of relevant vaccines.

Fig.1 Structure of tumor-associated globo H antigen. (Mandal, et al., 2015)

Tumor-Associated Globo Antigen Production Service at CD BioGlyco

CD BioGlyco has developed a Vaccine Development Platform dedicated to the Development of Carbohydrate Vaccines. In this type of vaccine development, we provide services such as the development of tumor-related vaccines and the production of tumor-related antigens. Specifically, we produce tumor-associated antigens including but not limited to.

Fig.2 Types of Globo antigens we synthesize. (CD BioGlyco)

Applications

• Globo antigen is overexpressed in a wide range of tumor cells, so it can be used to detect the production of tumor cells.
• Globo antigen can be used to develop tumor-related vaccines.
• In the medical field, globo antigens can be used in oncology and cancer treatment research.

Advantages

• We provide a complete range of globo antigen services from production to vaccine development.
• We have a strong vaccine research and development platform, and professional researchers to develop a suitable antigen production program for our clients.

CD BioGlyco focuses on the development of carbohydrate vaccines. We have successfully mastered the production of tumor-associated Globo antigens. If you are interested in our services, please feel free to contact us.

References

1. Chiang, Y.C.; et al. A concise chemoenzymatic total synthesis of neutral globo-series glycosphingolipids globo A and globo B, and Forssman and para-Forssman antigens. Glycoconjugate Journal. 2023.
2. Mandal, S.S.; et al. Chemical synthesis of the tumor-associated globo H antigen. RSC Adv. 2015, 5(30): 23311-23319.