p38-MAPK inhibitor Losmapimod, Purity ≥98%

Synonym: Losmapimod; 585543-15-3; GSK-AHAB; GW856553; GW856553X; GW-856553; GSKAHAB; p38-MAPK inhibitor

MDL: MFCD16619322
CAS Number: 585543-15-3
Compound CID: 11552706

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

Losmapimod, soluble in DMSO and warmed ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38α and p38β.

Molecular Weight

383.46

Molecular Formula

C₂₂H₂₆FN₃O₂

Targets

p38α: 8.1 (pKi); p38β: 7.6 (pKi)

Form

Lyophilized powder

Purity

Solubility

DMSO: 72 mg/mL (187.76 mM); Water: Insoluble; Warmed ethanol: 39 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

Losmapimod is applied in research targeting the inhibition of p38 MAP kinase activity and its effects on inflammatory and cardiovascular diseases.