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p38-MAPK inhibitor SB 203580, Purity ≥98%
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Cat. No.: X23-10-ZQ881

p38-MAPK inhibitor SB 203580, Purity ≥98%

Synonym: 152121-47-6; SB 203580; SB-203580; SB203580; 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole; Adezmapimod; 4-[4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine; p38-MAPK inhibitor

  • MDL: MFCD00922198
  • CAS Number: 152121-47-6
  • Compound CID: 176155
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Product Size
25 mg; 50 mg; 100 mg; 200 mg
Price
Datasheet
MSDS
Properties
Description
SB 203580, soluble in DMSO and insoluble in ethanol and water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38 MAPK (THP-1 cells) and PKB (THP-1 cells).
Molecular Weight
377.4
Molecular Formula
C21H16FN3OS
Targets
p38 MAPK (THP-1 cells): 0.3-0.5 μM; PKB (THP-1 cells): 3-5 μM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 40 mg/mL (105.97 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
SB 203580 can be used to study the inhibition of p38 MAP kinase and its effects on cellular stress response.
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