p38-MAPK inhibitor SB 239063, Purity ≥98%

Synonym: 193551-21-2; SB 239063; SB-239063; SB239063; Cyclohexanol, 4-(4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans-; Trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole; p38-MAPK inhibitor

MDL: MFCD03792786
CAS Number: 193551-21-2
Compound CID: 5166

Product Size

2 mg; 5 mg; 10 mg; 25 mg

Price

Datasheet

MSDS

Properties

Description

SB 239063, soluble in DMSO and warmed ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38α and p38β.

Molecular Weight

368.4

Molecular Formula

C₂₀H₂₁FN₄O₂

Targets

p38α: 44 nM; p38β: 44 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 59 mg/mL (160.15 mM); Water: Insoluble; Warmed ethanol: 7 mg/mL (19 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

SB 239063 is utilized to study the inhibition of the p38 MAP kinase pathway with a focus on inflammation and cellular stress response.