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p38-MAPK inhibitor VX-745, Purity ≥98%
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Cat. No.: X23-10-ZQ902

p38-MAPK inhibitor VX-745, Purity ≥98%

Synonym: 209410-46-8; VX-745; Neflamapimod; 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one; VX 745; VX745; 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one; p38-MAPK inhibitor

  • MDL: MFCD09834070
  • CAS Number: 209410-46-8
  • Compound CID: 3038525
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
MSDS
Properties
Description
VX-745, soluble in DMSO and insoluble in ethanol and water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38α and p38β.
Molecular Weight
436.3
Molecular Formula
C19H9Cl2F2N3OS
Targets
p38α: 10 nM; p38β: 220 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 15 mg/mL (34.38 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
VX-745 is used to examine the selective inhibition of p38α MAP kinase for therapeutic potential in neuroinflammation and neurodegenerative disorders.
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